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Acetaminophen and codeine phosphate tablets may well impair the psychological or Actual physical capabilities needed to perform possibly harmful routines for example driving a vehicle or running machinery.

Two-calendar year carcinogenicity research are already conducted in F344/N rats and B6C3F1 mice. There was no proof of carcinogenicity in male and woman rats, respectively, at dietary doses up to 70 and 80 mg/kg/day of codeine sulfate (approximately two occasions the maximum advised daily dose of 360 mg/day for Grownups over a mg/m2 basis) for two several years.

Concomitant use ought to be reserved for use in individuals for whom option cure selections are inadequate. If necessary, Restrict dose and duration towards the minimal needed and follow patients for signs and signs and symptoms of respiratory depression and sedation.

Postoperative management in children more youthful than 18 yrs of age adhering to tonsillectomy and/or adenoidectomy (see WARNINGS).

While severe, existence-threatening, or fatal respiratory depression can take place Anytime through the usage of acetaminophen and codeine phosphate tablets, the danger is biggest over the initiation of therapy or pursuing a dosage maximize.

You might have some acetaminophen and codeine phosphate tablets still left in excess of that you didn't use. See disposal data at the bottom of the area for directions regarding how to safely and securely throw away (eliminate) your unused acetaminophen and codeine phosphate tablets.

Due to the challenges of read more addiction, abuse and misuse, the lowest dose to the shortest period in keeping with unique patient treatment objectives needs websitehere to be utilised.

Parenteral drug abuse is often related to transmission read more of infectious ailments such as hepatitis and HIV.

Acetaminophen and codeine may well enhance the neuromuscular blocking motion of skeletal muscle mass relaxants and create a heightened diploma of respiratory melancholy.

Just like Grown ups, when prescribing codeine for adolescents, healthcare suppliers should pick the most affordable powerful dose for the shortest length of time and notify individuals and caregivers about these risks as well as indications of morphine overdose (see OVERDOSAGE).

Advise sufferers having acetaminophen and codeine phosphate tablets not to utilize MAOIs or in fourteen days of halting this kind of treatment method. If urgent utilization of an opioid is essential, use check doses and Regular titration of smaller doses of other opioids (like oxycodone, hydrocodone, oxymorphone, hydrocodone, or buprenorphine) to deal with pain although intently monitoring blood pressure level and signals and indicators of CNS and respiratory despair.

The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complicated.

pregnant or intending to turn out to be Expecting. Prolonged usage of Acetaminophen and Codeine Phosphate Tablets, USP in the course of pregnancy can cause withdrawal signs or symptoms within your new child child that could be lifetime-threatening if not regarded and taken care of.

Repeated interaction concerning associates on the Health care group, individuals, as well as their caregiver/spouse and children is essential for the duration of durations of changing analgesic needs; if the extent of suffering increases right after dose stabilization, check here an try need to be built to determine the source of greater agony prior to rising the dose of suffering medication.